Ortiz, O., Delgado-García, J.M., Espadas, I., Bahí, A., Trullas, R., Dreyer, J.L., Gruart, A. and Moratalla R.
Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null, Drd1a-/- mice and in hippocampal siRNA silenced Drd1a mice.
The Journal of Neuroscience,30(37), 12288-12300.
Pubmed

López-Ramos J.C., Tomioka, Y., Morimatsu, M., Yamamoto, S., Ozaki, K., Ono, E. and Delgado-García J.M.
Motor-coordination-dependent learning, more than others, is impaired in transgenic mice expressing pseudorabies virus immediate-early protein IE180.
PLoS One, 5(8) e12123.
Pubmed

Madroñal, N., López-Aracil, C., Rangel, A., del Río, J.A., Delgado-García, J.M. and Gruart, A.
Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.
PlosONE, 5(6) e11130, 1-10.
Pubmed

Porras-García, E., Sánchez-Campusano, R., Martínez-Vargas, D., Domínguez-del-Toro, E., Cendelín, J., Vozeh, F. and Delgado-García, J.M.
Behavioral characteristics, associative learning capabilities, and dynamic association mapping in an animal model of cerebellar degeneration.
Journal of Neurophysiology, 104(1):346-365.
Pubmed

Rodríguez-Bies, E., Santa-Cruz Calvo, S., Fontán-Lozano, A., Peña Amaro, J., Berral de la Rosa, F.J., Carrión, A.M., Navas, P. and López-Lluch G.
Muscle physiology changes induced by every other day feeding and endurance exercise in mice: effects on physical performance.
PLoS One, 5(11). e13900.
Pubmed

Madroñal, N., Gruart, A., Sacktor, T.C. and Delgado-García, J.M.
PKMzeta inhibition reverses learning-induced increases in hippocampal synaptic strength and memory during trace eyeblink conditioning.
PlosONE, 5(4) e10400, 1-8.
Pubmed

Márquez-Ruiz, J. and Escudero, M.
Eye movements and abducens motoneuron behavior after cholinergic activation of the nucleus reticularis pontis caudalis.
Sleep, 33(11), 1517-1527.
Pubmed 

Fontán-Lozano, A., Suárez-Pereira, I., Horrillo, A., del-Pozo-Martín, Y., Hmadcha, A. and Carrión A.M.
Histone H1 poly[ADP]-ribosylation regulates the chromatin alterations required for learning consolidation.
Journal of Neuroscience, 30(40), 13305-13313.
Pubmed

Pujadas, L., Gruart, A., Bosch, C., Delgado, L., Teixeira, C.M., Rossi, D., de Lecea, L., Martínez, A., Delgado-García, J.M. and Soriano E.
Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation.
The Journal of Neuroscience, 30(13), 4636-4649.
Pubmed

Clarke, J.R., Cammarota, M., Gruart, A., Izquierdo, I. y Delgado-Garcúa, J.M.
Plastic modifications induced by object recognition memory processing.
Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(6), 2652-2657.
Pubmed

Romero-Granados, R., Fontán-Lozano, A., Delgado-García, J.M. and Carrión, A.M.
From learning to forgetting: behavioral, circuitry, and molecular properties define the different functional states of the recognition memory trace.
Hippocampus, 20(5), 584-595.
Pubmed

Rangel, A., Madroñal, N., Gruart, A., Gavín, R., Llorens, F., Sumory, L., Torres, J.M., Delgado-García, J.M. and Del Río, J.A.
Regulation of GABA_A and glutamate receptor expression, synaptic facilitation and long-term potentiation in the hippocampus of prion mutant mice.
PlosONE, 4(10) e7592, 1-14.
Pubmed

Pereira, P.L., Magnol, L., Sahún, I., Brault, V., Duchon, A., Prandini, P., Gruart, A., Bizot, J-Ch., Chadefaux-Vekemans, B., Deutsch, S., Trovero, F., Delgado-García, J.M., Antonarakis, S.E., Dierssen, M. and Herault, Y.
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of Down syndrome.
Human Molecular Genetics, 18(24), 4756-4769.
Pubmed

Sánchez-Campusano, R., Gruart, A. and Delgado-García, J.M.
Dynamic associations in the cerebellar-motoneuron network during motor learning.
The Journal of Neuroscience, 29(34), 10750-10763.
Pubmed

Fernández-Lamo, I., Montero-Pedrazuela, A., Delgado-García, J.M., Guadaño-Ferraz, A. and Gruart, A.
Effects of thyroid hormona replacement on associative learning and hippocampal synaptic plasticity in adult hypothyroid rats.
European Journal of Neuroscience, 30, 679-692.
Pubmed

Musumeci, G., Sciarretta, C., Rodríguez-Moreno, A., Al Banchaabouchi, M., Negrete-Díaz, V., Costanzi, M., Berno, V., Egorov, A.V., von Bohlen Und Halbach, O., Cestari, V., Delgado-García, J.M. and Minichiello, L.
TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites.
The Journal of Neuroscience, 29(32), 10131-10143.
Pubmed

Márquez-Ruiz, J. and Escudero, M.
Eye movements and abducens motoneuron behavior during cholinergically induced REM sleep.
Sleep, 32(4), 471-481.
Pubmed

Madroñal, N., Gruart, A. and Delgado-García, J.M.
Differing presynaptic contributions to LTP and to associative learning in alert behaving mice.
Frontiers in Behavioral Neuroscience, 3, 1-14.
Pubmed

Fontinha, B.M., Delgado-García, J.M., Madroñal, N., Sebastião, A.M. and Gruart, A.
Adenosine A_2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice.
Neuropsychopharmacology, 34, 1865-1874.
Pubmed

Fontán-Lozano, A., Romero-Granados, R., del-Pozo-Martín, Y., Suárez-Pereira, I., Delgado-García, J.M., Penninger, J.M. and Carrión, A.M.
Lack of DREAM protein enhances learning and memory and slows brain aging.
Current Biology, 19(1), 54-60. Erratum in: Current Biology, 19(15):1332.
Pubmed

Delgado-García, J.M. and Gruart, A.
An experimental model for the study of cognitive disorders; the hippocampus and associative learning in mice.
Neurotoxicity Research, 14 (4), 359-366.
Pubmed

Fontán-Lozano, A., López-Lluch, G., Delgado-García, J.M., Navas. P. and Carrión, A.M.
Molecular bases of caloric restriction regulation of neuronal synaptic plasticity.
Molecular Neurobiology, 38(2):167-177.
Pubmed

Márquez-Ruiz, J. and Escudero, M.
Tonic and phasic phenomena underlying eye movements during sleep in the cat.
The Journal of Physiology, 586(14), 3461-3477.
Pubmed

Escudero, M. and Márquez-Ruiz, J.
Tonic inhibition and ponto-geniculo-occipital-related activities shape abducens motoneuron discharge during REM sleep.
The Journal of Physiology, 586(14), 3479-3491.
Pubmed

Fontán-Lozano, A., Romero-Granados, R., Troncoso, J., Múnera, A., Delgado-García, J.M. and Carrión A.M.
Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice.
Molecular and Cellular Neuroscience, 39(2):193-201.
Pubmed

Geraldi, P., Delgado-García, J.M. and Gruart, A.
Acute and repeated effects of three organophosphorus pesticides on the acquisition and retention of an instrumental learning task in rats.
Neurotoxicity Research, 13 (3-4), 253-263.
Pubmed

Gruart, A., López-Ramos, J.C., Muñoz, M.D. and Delgado-García, J.M.
Aged wild-type and APP, PS1, and APP+PS1 mice present similar deficits in associative learning and synaptiuc plasticity independent of amyloid load.
Neurobiology of Disease, 30, 439-450.
Pubmed

Gil-Sanz, C., Delgado-García, J.M., Fairén, A. and Gruart, A.
Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice.
Cerebral Cortex, 18, 1653-1663.
Pubmed

Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression.
Castelán F, Castillo M, Mulet J, Sala S, Sala F, Domínguez Del Toro E, Criado M.
Journal of Neurochemistry, 105(3), 617-627.
Pubmed

Eleore, L., López-Ramos, J.C., Yi, P.J. and Delgado-García, J.M.
The cognitive enhancer T-588 partially compensates the motor associative learning impairments induced by scopolamine injection in mice.
Behavioral Neuroscience, 121(6):1203-1214.
Pubmed

Madroñal, N., Delgado-García, J.M. and Gruart, A.
Differential effects of long-term potentiation evoked at the CA3-CA1 synapse prior to, during, and after the acquisition of classical eyeblink conditioning in behaving mice.
Journal of Neuroscience, 27(45), 12139-12146.
Pubmed

Jiménez-Díaz, L., Gruart A., Miñano, F.J. and Delgado-García, J.M.
Extracellular amino acid levels in the interpositus nucleus during classical eyeblink conditioning in alert cats.
Behavioral Neuroscience, 121(5), 1106-1112.
Pubmed

Guimarães, L., Domínguez-del-Toro, E., Chatonnet, F., Wrobel, L., Pujades, C., Monteiro, L.S. and Champagnat, J.
Exposure to retinoic acid at the onset of hindbrain segmentation induces episodic breathing in mice.
European Journal of Neuroscience, 25(12), 3526-3536.
Pubmed

Márquez-Ruiz, J., Morcuende, S., Navarro-López, J. de D. and Escudero, M.
Anatomical and pharmacological relationship between acetylcholine and nitric oxide in the prepositus hypoglossi nucleus of the cat: functional implications for eye-movement control.
The Journal of Comparative Neurology, 503(3), 407-420.
Pubmed

Gruart, A. and Delgado-García, J.M.
Activity-dependent changes of the hippocampal CA3-CA1 synapse during the acquisition of associative learning in conscious mice.
Genes, Brain and Behavior, 6, 24-31.
Pubmed

Sáez-Cassanelli, J.L., Fontanella, G.H., Delgado-García, J.M. and Carrión, A.M.
Functional blockage of the cannabinoid receptor type 1 evokes a kappa-opiate-dependent analgesia.
Journal of Neurochemistry, 103(6):2629-2639.
Pubmed

Leal-Campanario, R., Fairén, A., Delgado-García, J.M. and Gruart, A.
Electrical stimulation of the rostral medial prefrontal cortex in rabbits inhibits the expression of conditioned eyelid responses but not their acquisition.
Proceedings of the National Academy of Sciences of the United States of America (PNAS), 104(27), 11459-11464.
Pubmed

Sánchez-Campusano, R., Gruart, A. and Delgado-García, J.M.
The cerebellar interpositus nucleus and the dynamic control of learned motor responses.
The Journal of Neuroscience, 27(25), 6620-6632.
Pubmed

Sahún, I., Delgado-García, J.M., Amador-Arjona, A., Giralt, A., Alberch, J., Dierssen, M. and Gruart, A.
Dissociation between CA3-CA1 synaptic plasticity and associative learning in TgNTRK3 transgenic mice.
Journal of Neuroscience, 27(9), 2253-2260.
Pubmed

Fontán-Lozano, A., Sáez-Cassanelli, J.L., Inda, M.C., de los Santos-Arteaga, M., Sierra-Domínguez, S.A., López-Lluch, G., Delgado-García, J.M. and Carrión, A.M.
Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor.
Journal of Neuroscience, 27(38):10185-10195.
Pubmed

Valenzuela-Harrington, M., Gruart, A. and Delgado-García, J.M.
Contribution of NMDA receptor NR2B subunit to synaptic plasticity during associative learning in behaving rats.
European Journal of Neuroscience, 25, 830-836.
Pubmed

Gruart, A., Sciarretta, C., Valenzuela-Harrington, M., Delgado-García, J.M. and Minichiello, L.
Mutation at the TrkB-PLCγ-docking site affects hippocampal LTP and associative learning in conscious mice.
Learning and Memory, 14(1), 54-62.
Pubmed

López-Ramos, J.C., Yi, P.J., Eleore, L., Madroñal, N., Rueda, A. and Delgado-García, J.M.
Classical eyeblink conditioning during acute hypobaric hypoxia is improved in acclimatized mice and involves Fos expression in selected brain areas.
Journal of Applied Physiology, 103(5), 1479-1487.
Pubmed

Negrete-Díaz, J.V., Sihra, T.S., Delgado-García, J.M. and Rodríguez-Moreno, A.
Kainate receptor-mediated presynaptic inhibition converges with presynaptic inhibition mediated by Group II mGluRs and long-term depression at the hippocampal mossy fiber-CA3 synapse.
Journal of Neural Transmission,114(11), 1425-1431.
Pubmed

Troncoso, J., Múnera, A. and Delgado-García, J.M.
Learning-dependent potentiation in the vibrissal motor cortex is closely related to the acquisition of conditioned whisker responses in behaving mice.
Learning & Memory, 14(1-2), 84-93.
Pubmed

Jiménez-Díaz, L., Gruart, A., Sancho-Bielsa, F.J., López-García, C. and Delgado-García, J.M.
Evolution of cerebral cortex involvement in the acquisition of associative learning.
Behavioral Neuroscience, 120(5), 1043-1056.
Pubmed

Gottlieb, M., Leal-Campanario, R., Campos-Esparza, M.R., Sánchez-Gómez, M.V., Alberdi, E., Arranz, A., Delgado-García, J.M., Gruart, A. and Matute, C.
Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia.
Neurobiology of Disease, 23, 374-386.
Pubmed

Navarro-López, J. de D., Yajeya, J. and Delgado-García, J.M.
A cholinergic mechanism for eye fixation.
Journal of Molecular Neuroscience, 30(1-2), 125-128.
Pubmed

Leal-Campanario, R., Delgado-García, J. M. and Gruart, A.
Microstimulation of the somatosensory cortex can substitute for vibrissa stimulation during Pavlovian conditioning.
Proceedings of the National Academy of Sciences of the United States of America (PNAS), 103(26), 10052-10057.
Pubmed

Delgado-García, J.M. and Gruart, A.
Building new motor responses: eyelid conditioning revisited.
Trends in Neurosciences, 29(6), 330-338.
Pubmed

Gruart, A., Muñoz, M.D. and Delgado-García, J.M.
Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice.
Journal of Neuroscience, 26 (4), 1077-1087.
Pubmed

Negrete-Díaz, J.V., Sihra, T.S., Delgado-García, J.M. and Rodríguez-Moreno, A.
Kainate receptor-mediated inhibition of glutamate release involves protein kinase A in the mouse hippocampus.
Journal of Neurophysiology, 96(4):1829-1837.
Pubmed

Rodríguez-Moreno, A., Carrión, M. and Delgado-García, J.M.
The nicotinic agonist RJR-2403 compensates the impairment of eyeblink conditioning produced by the noncompetitive NMDA-receptor antagonist MK-801.
Neuroscience Letters, 402(1-2):102-107.
Pubmed